| 07. Apr | Feyenoord | - | Slavia Praha | 3 | : | 3 | |
| 14. Apr | Slavia Praha | - | Feyenoord | 1 | : | 3 | |
| Feyenoord | - | Slavia Praha | 6 | : | 4 | ||
| 07. Apr | FK Bodø/Glimt | - | AS Roma | 2 | : | 1 | |
| 14. Apr | AS Roma | - | FK Bodø/Glimt | 4 | : | 0 | |
| FK Bodø/Glimt | - | AS Roma | 2 | : | 5 | ||
| 07. Apr | Olympique Marseille | - | PAOK Saloniki | 2 | : | 1 | |
| 14. Apr | PAOK Saloniki | - | Olympique Marseille | 0 | : | 1 | |
| Olympique Marseille | - | PAOK Saloniki | 3 | : | 1 | ||
| 07. Apr | Leicester City | - | PSV Eindhoven | 0 | : | 0 | |
| 14. Apr | PSV Eindhoven | - | Leicester City | 1 | : | 2 | |
| Leicester City | - | PSV Eindhoven | 2 | : | 1 | ||
Viertelfinale - Europa Conference League 2021/22
