| 21. Jan | Atalanta | - | Sturm Graz | 5 | : | 0 | |
| AS Monaco | - | Aston Villa | 1 | : | 0 | ||
| Liverpool FC | - | Lille OSC | 2 | : | 1 | ||
| Atlético Madrid | - | Bayer Leverkusen | 2 | : | 1 | ||
| SL Benfica | - | FC Barcelona | 4 | : | 5 | ||
| Club Brugge KV | - | Juventus | 0 | : | 0 | ||
| Crvena Zvezda | - | PSV Eindhoven | 2 | : | 3 | ||
| Bologna FC | - | Borussia Dortmund | 2 | : | 1 | ||
| Slovan Bratislava | - | VfB Stuttgart | 1 | : | 3 | ||
| 22. Jan | RB Leipzig | - | Sporting CP | 2 | : | 1 | |
| Shakhtar Donetsk | - | Stade Brestois 29 | 2 | : | 0 | ||
| Paris Saint-Germain | - | Manchester City | 4 | : | 2 | ||
| Real Madrid | - | FC Salzburg | 5 | : | 1 | ||
| AC Milan | - | Girona FC | 1 | : | 0 | ||
| Arsenal FC | - | Dinamo Zagreb | 3 | : | 0 | ||
| Celtic FC | - | BSC Young Boys | 1 | : | 0 | ||
| Feyenoord | - | FCB München | 3 | : | 0 | ||
| AC Sparta Praha | - | Inter | 0 | : | 1 | ||